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Research suggests that lower caffeine doses can still provide meaningful benefits for endurance activities while minimizing the risk of jitters or anxiety that could disrupt steady-state training

Patients frequently endure pain, muscle cramps, sleep disturbances, psychological distress, and gastrointestinal issues, significantly impairing their quality of life

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This is why some people take very high doses, such as 1500 mg or even 2000 mg, in hopes that at least some will make it through

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